Proteasomal Degradation of Indoleamine 2,3-Dioxygenase in CD8+ Dendritic Cells is Mediated by Suppressor of Cytokine Signaling 3 (SOCS3)

Proteasomal Degradation of Indoleamine 2,3-Dioxygenase in CD8+ Dendritic Cells is Mediated by Suppressor of Cytokine Signaling 3 (SOCS3)

Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step of tryptophan catabolism in a specific pathway, resulting in a series of extracellular messengers collectively known as kynurenines. IDO has been recognized as an authentic regulator of immunity not only in mammalian preg...

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Bibliographic Details
Main Authors:	Pallotta, Maria T., Orabona, Ciriana, Volpi, Claudia, Grohmann, Ursula, Puccetti, Paolo, Fallarino, Francesca
Format:	Online
Language:	English
Published:	Libertas Academica 2010
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195250/

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