CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice

CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice

Prediabetes and diabetes in nonobese diabetic (NOD) mice have been targeted by a variety of immunotherapies, including the use of a soluble form of cytotoxic T lymphocyte antigen 4 (CTLA-4) and interferon (IFN)-γ. The cytokine, however, fails to activate tolerogenic properties in dendritic cells (DC...

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Bibliographic Details
Main Authors: Fallarino, Francesca, Bianchi, Roberta, Orabona, Ciriana, Vacca, Carmine, Belladonna, Maria L., Fioretti, Maria C., Serreze, David V., Grohmann, Ursula, Puccetti, Paolo
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211844/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211844/

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