Distinct roles of immunoreceptor tyrosine‐based motifs in immunosuppressive indoleamine 2,3‐dioxygenase 1

Distinct roles of immunoreceptor tyrosine‐based motifs in immunosuppressive indoleamine 2,3‐dioxygenase 1

The enzyme indoleamine 2,3‐dioxygenase 1 (IDO1) catalyses the initial, rate‐limiting step in tryptophan (Trp) degradation, resulting in tryptophan starvation and the production of immunoregulatory kynurenines. IDO1's catalytic function has long been considered as the one mechanism responsible f...

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Bibliographic Details
Main Authors: Albini, Elisa, Rosini, Verdiana, Gargaro, Marco, Mondanelli, Giada, Belladonna, Maria L., Pallotta, Maria Teresa, Volpi, Claudia, Fallarino, Francesca, Macchiarulo, Antonio, Antognelli, Cinzia, Bianchi, Roberta, Vacca, Carmine, Puccetti, Paolo, Grohmann, Ursula, Orabona, Ciriana
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192792/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192792/

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