Fludarabine Downregulates Indoleamine 2,3-Dioxygenase in Tumors via a Proteasome-Mediated Degradation Mechanism

Fludarabine Downregulates Indoleamine 2,3-Dioxygenase in Tumors via a Proteasome-Mediated Degradation Mechanism

Indoleamine 2,3-dioxygenase (IDO) is found in multiple malignancies and exerts immunosuppressive effects that are central in protecting tumors from host T lymphocyte rejection. IDO is an enzyme involved in the catabolism of tryptophan resulting in inhibition of T lymphocyte function. While inhibitio...

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Bibliographic Details
Main Authors: Hanafi, Laïla-Aïcha, Gauchat, Dominique, Godin-Ethier, Jessica, Possamaï, David, Duvignaud, Jean-Baptiste, Leclerc, Denis, Grandvaux, Nathalie, Lapointe, Réjean
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050125/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050125/

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