µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis

µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis

Anti-apoptotic Bfl-1 and pro-apoptotic Bax, two members of the Bcl-2 family sharing a similar structural fold, are classically viewed as antagonist regulators of apoptosis. However, both proteins were reported to be death inducers following cleavage by the cysteine protease µ-calpain. Here we demons...

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Bibliographic Details
Main Authors: Valero, Juan García, Cornut-Thibaut, Aurélie, Jugé, Romain, Debaud, Anne-Laure, Giménez, Diana, Gillet, Germain, Bonnefoy-Bérard, Nathalie, Salgado, Jesús, Salles, Gilles, Aouacheria, Abdel, Kucharczak, Jérôme
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379997/

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