The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1

The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1

Gemcitabine is used to treat several cancers including lung cancer. However, tumor cells often escape gemcitabine-induced cell death via various mechanisms, which include modulating bcl-2 family members and NF-κB activation. We previously reported that the C-terminal region of Bfl-1 fused with GFP (...

Full description

Bibliographic Details
Main Authors:	Kim, Min-Kyoung, Jeon, Yoon-Kyung, Woo, Jong-Kyu, Choi, Yun, Choi, Dae-Han, Kim, Yeul-Hong, Kim, Chul-Woo
Format:	Online
Language:	English
Published:	BioMed Central 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166274/

Similar Items

A1/Bfl-1 in leukocyte development and cell death
by: Ottina, Eleonora, et al.
Published: (2012)

Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.
by: Yoon, Ho-Sung, et al.
Published: (2003)

Anti-Apoptotic Bfl-1 Is the Major Effector in Activation-Induced Human Mast Cell Survival
by: Ekoff, Maria, et al.
Published: (2012)

Ds tagging of BRANCHED FLORETLESS 1 (BFL1) that mediates the transition from spikelet to floret meristem in rice (Oryza sativa L)
by: Zhu, Qian-Hao, et al.
Published: (2003)

µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis
by: Valero, Juan García, et al.
Published: (2012)

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B
by: Rooswinkel, R W, et al.
Published: (2012)

Agelasine D Suppresses RANKL-Induced Osteoclastogenesis via Down-Regulation of c-Fos, NFATc1 and NF-κB
by: Kang, Moo Rim, et al.
Published: (2014)

Down-Regulation of NF-κB Target Genes by the AP-1 and STAT Complex during the Innate Immune Response in Drosophila
by: Kim, Lark Kyun, et al.
Published: (2007)

Anthocyanins Downregulate Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglial Cells by Suppressing the NF-κB and Akt/MAPKs Signaling Pathways
by: Jeong, Jin-Woo, et al.
Published: (2013)

Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt
by: Cheol Park, et al.
Published: (2018-08-01)

Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity
by: Cho, Seok-Cheol, et al.
Published: (2015)

The RCAN1 inhibits NF-κB and suppresses lymphoma growth in mice
by: Liu, C, et al.
Published: (2015)

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells
by: Lee, Jong-Kuen, et al.
Published: (2013)

Oleanane-triterpenoids from Panax stipuleanatus inhibit NF-κB
by: Liang, Chun, et al.
Published: (2013)

Suppression of NF-κB Reduces Myocardial No-Reflow
by: Zeng, Min, et al.
Published: (2012)

Kaempferol Suppresses Transforming Growth Factor-β1–Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-1791
by: Jo, Eunji, et al.
Published: (2015)

Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways
by: Park, So Youn, et al.
Published: (2016)

Roles of TLR7 in Activation of NF-κB Signaling of Keratinocytes by Imiquimod
by: Li, Zheng Jun, et al.
Published: (2013)

Intracellular annexin A2 regulates NF-κB signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer
by: Jung, H, et al.
Published: (2015)

Inhibitory Effects of Palmultang on Inflammatory Mediator Production Related to Suppression of NF-κB and MAPK Pathways and Induction of HO-1 Expression in Macrophages
by: Oh, You-Chang, et al.
Published: (2014)

Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR–IκB Kinase–NF-κB Pathways in Dendritic Cells
by: Ko, Su Hyuk, et al.
Published: (2016)

NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function
by: Sun, Fan, et al.
Published: (2015)

LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-κB Pathways
by: Lee, Seung Jin, et al.
Published: (2015)

Tat-DJ-1 inhibits oxidative stress-mediated RINm5F cell death through suppression of NF-κB and MAPK activation
by: Jo, Hyo Sang, et al.
Published: (2016)

A New Herbal Formula, KSG-002, Suppresses Breast Cancer Growth and Metastasis by Targeting NF-κB-Dependent TNFα Production in Macrophages
by: Woo, Sang-Mi, et al.
Published: (2013)

Deficiency of C-C Chemokine Receptor 5 Suppresses Tumor Development via Inactivation of NF-κB and Upregulation of IL-1Ra in Melanoma Model
by: Song, Ju Kyoung, et al.
Published: (2012)

Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2
by: Kim, Kyun Ha, et al.
Published: (2013)

CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling
by: Lee, Jeonggi, et al.
Published: (2011)

(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of inflammatory responses via inhibition of Src, Syk, and NF-κB
by: Kim, Yong, et al.
Published: (2016)

Swiprosin-1 Expression Is Up-Regulated through Protein Kinase C-θ and NF-κB Pathway in T Cells
by: Kim, Young-Dae, et al.
Published: (2013)

Oral administration of fermented wild ginseng ameliorates DSS-induced acute colitis by inhibiting NF-κB signaling and protects intestinal epithelial barrier
by: Seong, Myeong A, et al.
Published: (2015)

NFκB mediates IL-1β-induced down-regulation of TβRII through the modulation of Sp3 expression
by: Baugé, C, et al.
Published: (2008)

Suberoylanilide hydroxamic acid suppresses hepatic stellate cells activation by HMGB1 dependent reduction of NF-κB1
by: Wang, Wenwen, et al.
Published: (2015)

MicroRNA 135a Suppresses Lymph Node Metastasis through Down-Regulation of ROCK1 in Early Gastric Cancer
by: Shin, Ji-Young, et al.
Published: (2014)

Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks
by: Shon, Woo-Jeong, et al.
Published: (2015)

Siglecg Limits the Size of B1a B Cell Lineage by Down-Regulating NFκB Activation
by: Ding, Cheng, et al.
Published: (2007)

LPS Down-Regulates Specificity Protein 1 Activity by Activating NF-κB Pathway in Endotoxemic Mice
by: Ye, Xiaobing, et al.
Published: (2015)

Methanol Extract of Croton Pycnanthus Benth. Inhibits Osteoclast Differentiation by Suppressing the MAPK and NF-κB Signaling Pathways
by: Lee, Jiyeon, et al.
Published: (2014)

Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells
by: Kim, Mun-Ock, et al.
Published: (2011)

Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice
by: Shukla, Sanjeev, et al.
Published: (2015)