LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-κB Pathways
5-Lipoxygenase (5-LO) plays a pivotal role in the progression of atherosclerosis. Therefore, this study investigated the molecular mechanisms involved in 5-LO expression on monocytes induced by LPS. Stimulation of THP-1 monocytes with LPS (0~3 µg/ml) increased 5-LO promoter activity and 5-LO protein...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Korean Physiological Society and The Korean Society of Pharmacology
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422967/ |