NFκB mediates IL-1β-induced down-regulation of TβRII through the modulation of Sp3 expression
We previously showed that interleukin-1β (IL-1β) down-regulation of type II TGFβ receptor (TβRII) involves NFκB pathway and requires de novo synthesis of a yet unknown protein. Here, we demonstrate that this effect is mediated through Sp1 site located at position -25 of human TβRII promoter. Inhibit...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Blackwell Publishing Ltd
2008
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918091/ |