Somatic hypermutation of an immunoglobulin mu heavy chain transgene
We have analyzed somatic hypermutation of an immunoglobulin (Ig) heavy chain transgene. Hybridomas expressing the transgene were produced from immunized transgenic mice and transgene copies were sequenced to assay for mutation. In two IgM-producing hybridomas, as well as in several IgG-producing hyb...
| Format: | Online |
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| Language: | English |
| Published: |
The Rockefeller University Press
1993
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190889/ |