H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation

H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation

Changes in chromatin structure induced by posttranslational modifications of histones are important regulators of genomic function. Phosphorylation of histone H2AX promotes DNA repair and helps maintain genomic stability. Although B cells lacking H2AX show impaired class switch recombination (CSR),...

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Bibliographic Details
Main Authors: Reina-San-Martin, Bernardo, Difilippantonio, Simone, Hanitsch, Leif, Masilamani, Revati F., Nussenzweig, André, Nussenzweig, Michel C.
Format: Online
Language:English
Published: The Rockefeller University Press 2003
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193951/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193951/

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