Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity
In Heterodontus, a phylogenetically primitive shark species, the variable (VH), diversity (DH), joining (JH) segments, and constant (CH) exons are organized in individual approximately 18-20-kb "clusters." A single large VH family with > 90% nucleic acid homology and a monotypic second...
| Format: | Online |
|---|---|
| Language: | English |
| Published: |
The Rockefeller University Press
1993
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191167/ |