Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation
It is believed that immunoglobulin-variable region gene (IgV) somatic hypermutation (SHM) is initiated by activation-induced cytidine deaminase (AID) upon deamination of cytidine to deoxyuracil. Patch-excision repair of these lesions involving error prone DNA polymerases such as polη causes mutation...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2005
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213188/ |