Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data

Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data

Analyses of somatic hypermutation (SHM) patterns in B cell immunoglobulin (Ig) sequences contribute to our basic understanding of adaptive immunity, and have broad applications not only for understanding the immune response to pathogens, but also to determining the role of SHM in autoimmunity and B...

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Bibliographic Details
Main Authors: Yaari, Gur, Vander Heiden, Jason A., Uduman, Mohamed, Gadala-Maria, Daniel, Gupta, Namita, Stern, Joel N. H., O’Connor, Kevin C., Hafler, David A., Laserson, Uri, Vigneault, Francois, Kleinstein, Steven H.
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828525/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828525/

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