Identifying protein–protein interactions in somatic hypermutation
Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antibody–antigen binding. Cultured cell systems, mouse model systems, and human genetic deficiencies have been the key players in identifying likely SHM pathways, whereas “pure” biochemical approaches have been far les...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2005
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213056/ |