Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue

Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue

Activation of inflammation in white adipose tissue (WAT), includes infiltration/expansion of WAT macrophages, contributes pathogenesis of obesity, insulin resistance, and metabolic syndrome. The inflammasome comprises an intracellular sensor (NLR), caspase-1 and the adaptor ASC. Inflammasome activat...

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Bibliographic Details
Main Authors:	Ahmad, Faiyaz, Chung, Youn Wook, Tang, Yan, Hockman, Steven C., Liu, Shiwei, Khan, Yusuf, Huo, Kevin, Billings, Eric, Amar, Marcelo J., Remaley, Alan T., Manganiello, Vincent C.
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913246/

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