Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflammasome activation. NLRP3 inflammasome act...

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Bibliographic Details
Main Authors: Yang, Chul-Su, Kim, Jwa-Jin, Kim, Tae Sung, Lee, Phil Young, Kim, Soo Yeon, Lee, Hye-Mi, Shin, Dong-Min, Nguyen, Loi T., Lee, Moo-Seung, Jin, Hyo Sun, Kim, Kwang-Kyu, Lee, Chul-Ho, Kim, Myung Hee, Park, Sung Goo, Kim, Jin-Man, Choi, Hueng-Sik, Jo, Eun-Kyeong
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347017/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347017/

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