Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

Ataxia telangiectasia mutated (ATM) kinase plays an essential role in the maintenance of genomic stability. ATM-deficient (ATM−/−) mice exhibit hematopoietic stem cell (HSC) dysfunction and a high incidence of lymphoma. Gadd45a controls cell cycle arrest, apoptosis and DNA repair, and is involved in...

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Bibliographic Details
Main Authors:	Chen, Yulin, Yang, Runan, Guo, Peng, Ju, Zhenyu
Format:	Online
Language:	English
Published:	Higher Education Press 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938854/

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