Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular basis for this requirement is unknown. Here we show that a single, conserved NMD target, the mRNA coding for the stress response...

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Bibliographic Details
Main Authors: Nelson, Jonathan O, Moore, Kristin A, Chapin, Alex, Hollien, Julie, Metzstein, Mark M
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848089/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848089/

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