Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice
Ataxia telangiectasia mutated (ATM) kinase plays an essential role in the maintenance of genomic stability. ATM-deficient (ATM−/−) mice exhibit hematopoietic stem cell (HSC) dysfunction and a high incidence of lymphoma. Gadd45a controls cell cycle arrest, apoptosis and DNA repair, and is involved in...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Higher Education Press
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938854/ |