CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16

CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16

The insulin-like signaling pathway maintains a relatively short wild-type lifespan in Caenorhabditis elegans by phosphorylating and inactivating DAF-16, the ortholog of the FOXO transcription factors of mammalian cells. DAF-16 is phosphorylated by the AKT kinases, preventing its nuclear translocatio...

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Bibliographic Details
Main Authors: Tao, Li, Xie, Qi, Ding, Yue-He, Li, Shang-Tong, Peng, Shengyi, Zhang, Yan-Ping, Tan, Dan, Yuan, Zengqiang, Dong, Meng-Qiu
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691573/

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