Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans

Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans

Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the first recruitment profile of endogenous DAF-16 and show that the response is...

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Bibliographic Details
Main Authors: Kumar, Neeraj, Jain, Vaibhav, Singh, Anupama, Jagtap, Urmila, Verma, Sonia, Mukhopadhyay, Arnab
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747164/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747164/

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