Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging
Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively. Both are required for lifespan extension by reduced insulin/Igf signaling, and their activation in key tissues can exten...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969275/ |