Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels
Background: Two forms of PCSK9, an intact and a furin cleaved form, circulate in blood.
Main Authors: | Lipari, Michael T., Li, Wei, Moran, Paul, Kong-Beltran, Monica, Sai, Tao, Lai, Joyce, Lin, S. Jack, Kolumam, Ganesh, Zavala-Solorio, Jose, Izrael-Tomasevic, Anita, Arnott, David, Wang, Jianyong, Peterson, Andrew S., Kirchhofer, Daniel |
---|---|
Format: | Online |
Language: | English |
Published: |
American Society for Biochemistry and Molecular Biology
2012
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527935/ |
Similar Items
-
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gene Is a Risk Factor of Large-Vessel Atherosclerosis Stroke
by: Abboud, Shérine, et al.
Published: (2007) -
Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function
by: DeVay, Rachel M., et al.
Published: (2015) -
Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)
by: Schulz, Rainer, et al.
Published: (2015) -
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)
by: Canuel, Maryssa, et al.
Published: (2013) -
Efficacy and safety of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, alirocumab and evolocumab, a post-commercialization study
by: Joshua Choi, et al.
Published: (2017-07-01)