Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that promotes degradation of cell surface LDL receptors (LDLRs) in selected cell types. Here we used genetic and pharmacological inhibitors to define the pathways involved in PCSK9-mediated LDLR degradation. Inactivating mut...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The American Society for Biochemistry and Molecular
Biology
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413232/ |