Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria
Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as the nucleus, but details about its biology and function in the organelle remain largely unknown. Here we show, using multiple approaches, that mammalian TERT is mitochondrial, co-purifying with mitochondrial nucl...
Main Authors: | Sharma, Nilesh K., Reyes, Aurelio, Green, Paula, Caron, Matthieu J., Bonini, Marcelo G., Gordon, Donna M., Holt, Ian J., Santos, Janine Hertzog |
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Format: | Online |
Language: | English |
Published: |
Oxford University Press
2012
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258147/ |
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