Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as the nucleus, but details about its biology and function in the organelle remain largely unknown. Here we show, using multiple approaches, that mammalian TERT is mitochondrial, co-purifying with mitochondrial nucl...

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Bibliographic Details
Main Authors: Sharma, Nilesh K., Reyes, Aurelio, Green, Paula, Caron, Matthieu J., Bonini, Marcelo G., Gordon, Donna M., Holt, Ian J., Santos, Janine Hertzog
Format: Online
Language:English
Published: Oxford University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258147/