Telomerase reverse transcriptase moonlights: Therapeutic targets beyond telomerase
Telomeres, the repetitive sequences at chromosomal ends, protect intact chromosomes. Telomeres progressively shorten through successive rounds of cell divisions, and critically shortened telomeres trigger senescence and apoptosis. The enzyme that elongates telomeres and maintains their structure is...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
John Wiley and Sons Inc.
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714691/ |