Human telomerase reverse transcriptase binds to a pre-organized hTR in vivo exposing its template

Telomerase is a specialized reverse transcriptase that is responsible for telomere length maintenance. As in other organisms, the minimal components required for an active human telomerase are the template-providing telomerase RNA (hTR) and the enzymatic entity telomerase reverse transcriptase (hTER...

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Bibliographic Details
Main Authors: Zemora, Georgeta, Handl, Stefan, Waldsich, Christina
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705647/