Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

by Pizarro, Juan Carlos, Hills, Tanya, Senisterra, Guillermo, Wernimont, Amy K., Mackenzie, Claire, Norcross, Neil R., Ferguson, Michael A. J., Wyatt, Paul G., Gilbert, Ian H., Hui, Raymond
Published 2013

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

by Wu, Hong, Zeng, Hong, Dong, Aiping, Li, Fengling, He, Hao, Senisterra, Guillermo, Seitova, Alma, Duan, Shili, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl H., Schapira, Matthieu
Published 2013

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein*

by Eram, Mohammad S., Bustos, Susan P., Lima-Fernandes, Evelyne, Siarheyeva, Alena, Senisterra, Guillermo, Hajian, Taraneh, Chau, Irene, Duan, Shili, Wu, Hong, Dombrovski, Ludmila, Schapira, Matthieu, Arrowsmith, Cheryl H., Vedadi, Masoud
Published 2014

The Cryptosporidium parvum Kinome

by Artz, Jennifer D, Wernimont, Amy K, Allali-Hassani, Abdellah, Zhao, Yong, Amani, Mehrnaz, Lin, Yu-Hui, Senisterra, Guillermo, Wasney, Gregory A, Fedorov, Oleg, King, Oliver, Roos, Annette, Lunin, Vlad V, Qiu, Wei, Finerty, Patrick, Hutchinson, Ashley, Chau, Irene, von Delft, Frank, MacKenzie, Farrell, Lew, Jocelyne, Kozieradzki, Ivona, Vedadi, Masoud, Schapira, Matthieu, Zhang, Chao, Shokat, Kevan, Heightman, Tom, Hui, Raymond
Published 2011

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

by Senisterra, Guillermo, Wu, Hong, Allali-Hassani, Abdellah, Wasney, Gregory A., Barsyte-Lovejoy, Dalia, Dombrovski, Ludmila, Dong, Aiping, Nguyen, Kong T., Smil, David, Bolshan, Yuri, Hajian, Taraneh, He, Hao, Seitova, Alma, Chau, Irene, Li, Fengling, Poda, Gennadiy, Couture, Jean-François, Brown, Peter J., Al-Awar, Rima, Schapira, Matthieu, Arrowsmith, Cheryl H., Vedadi, Masoud
Published 2012

A cellular chemical probe targeting the chromodomains of Polycomb Repressive Complex 1

by Stuckey, Jacob I, Dickson, Bradley M, Cheng, Nancy, Liu, Yanli, Norris, Jacqueline L, Cholensky, Stephanie H, Tempel, Wolfram, Qin, Su, Huber, Katherine G, Sagum, Cari, Black, Karynne, Li, Fengling, Huang, Xi-Ping, Roth, Bryan L, Baughman, Brandi M, Senisterra, Guillermo, Pattenden, Samantha G, Vedadi, Masoud, Brown, Peter J, Bedford, Mark T, Min, Jinrong, Arrowsmith, Cheryl H, James, Lindsey I, Frye, Stephen V
Published 2016

RPRD1A and RPRD1B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser5 Dephosphorylation

by Ni, Zuyao, Xu, Chao, Guo, Xinghua, Hunter, Gerald O., Kuznetsova, Olga V., Tempel, Wolfram, Marcon, Edyta, Zhong, Guoqing, Guo, Hongbo, Kuo, Wei-Hung William, Li, Joyce, Young, Peter, Olsen, Jonathan B., Wan, Cuihong, Loppnau, Peter, El Bakkouri, Majida, Senisterra, Guillermo A., He, Hao, Huang, Haiming, Sidhu, Sachdev S., Emili, Andrew, Murphy, Shona, Mosley, Amber L., Arrowsmith, Cheryl H., Min, Jinrong, Greenblatt, Jack F.
Published 2014

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

by Grebien, Florian, Vedadi, Masoud, Getlik, Matthäus, Giambruno, Roberto, Grover, Amit, Avellino, Roberto, Skucha, Anna, Vittori, Sarah, Kuznetsova, Ekaterina, Smil, David, Barsyte-Lovejoy, Dalia, Li, Fengling, Poda, Gennadiy, Schapira, Matthieu, Wu, Hong, Dong, Aiping, Senisterra, Guillermo, Stukalov, Alexey, Huber, Kilian V. M., Schönegger, Andreas, Marcellus, Richard, Bilban, Martin, Bock, Christoph, Brown, Peter J., Zuber, Johannes, Bennett, Keiryn L., Al-awar, Rima, Delwel, Ruud, Nerlov, Claus, Arrowsmith, Cheryl H., Superti-Furga, Giulio
Published 2015