BRD4: A BET(ter) target for the treatment of AML?

by Valent, Peter, Zuber, Johannes
Published 2014

Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemi...

by Salmon, Jessica M, Bots, Michael, Vidacs, Eva, Stanley, Kym L, Atadja, Peter, Zuber, Johannes, Johnstone, Ricky W
Published 2015

Reversible Suppression of Cyclooxygenase 2 (COX-2) Expression In Vivo by Inducible RNA Interference

by Zaiss, Anne K., Zuber, Johannes, Chu, Chun, Machado, Hidevaldo B., Jiao, Jing, Catapang, Arthur B., Ishikawa, Tomo-o, Gil, Jose S., Lowe, Scott W., Herschman, Harvey R.
Published 2014

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat...

by Bigenzahn, Johannes W., Fauster, Astrid, Rebsamen, Manuele, Kandasamy, Richard K., Scorzoni, Stefania, Vladimer, Gregory I., Müller, André C., Gstaiger, Matthias, Zuber, Johannes, Bennett, Keiryn L., Superti-Furga, Giulio
Published 2016

Direct and indirect targeting of MYC to treat acute myeloid leukemia

by Brondfield, Sam, Umesh, Sushma, Corella, Alexandra, Zuber, Johannes, Rappaport, Amy R., Gaillard, Coline, Lowe, Scott W., Goga, Andrei, Kogan, Scott C.
Published 2015

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)

by Herrmann, Harald, Blatt, Katharina, Shi, Junwei, Gleixner, Karoline V., Cerny-Reiterer, Sabine, Müllauer, Leonhard, Vakoc, Christopher R., Sperr, Wolfgang R., Horny, Hans-Peter, Bradner, James E., Zuber, Johannes, Valent, Peter
Published 2012

Cooperative loss of RAS feedback regulation drives myeloid leukemognesis

by Zhao, Zhen, Chen, Chi-Chao, Rillahan, Cory D., Shen, Ronglai, Kitzing, Thomas, McNerney, Megan E., Diaz-Flores, Ernesto, Zuber, Johannes, Shannon, Kevin, Le Beau, Michelle M., Spector, Mona S., Kogan, Scott C., Lowe, Scott W.
Published 2015

Identification of bromodomain-containing protein 4 (BRD4) as a novel marker and epigenetic target in mast cell leukemia

by Wedeh, Ghaith, Cerny-Reiterer, Sabine, Eisenwort, Gregor, Herrmann, Harald, Blatt, Katharina, Hadzijusufovic, Emir, Sadovnik, Irina, Müllauer, Leonhard, Schwaab, Juliana, Hoffmann, Thomas, Bradner, James E., Radia, Deepti, Sperr, Wolfgang R., Hoermann, Gregor, Reiter, Andreas, Horny, Hans-Peter, Zuber, Johannes, Arock, Michel, Valent, Peter
Published 2015

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

by Grabner, Beatrice, Schramek, Daniel, Mueller, Kristina M., Moll, Herwig P., Svinka, Jasmin, Hoffmann, Thomas, Bauer, Eva, Blaas, Leander, Hruschka, Natascha, Zboray, Katalin, Stiedl, Patricia, Nivarthi, Harini, Bogner, Edith, Gruber, Wolfgang, Mohr, Thomas, Zwick, Ralf Harun, Kenner, Lukas, Poli, Valeria, Aberger, Fritz, Stoiber, Dagmar, Egger, Gerda, Esterbauer, Harald, Zuber, Johannes, Moriggl, Richard, Eferl, Robert, Győrffy, Balázs, Penninger, Josef M., Popper, Helmut, Casanova, Emilio
Published 2015

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

by Grebien, Florian, Vedadi, Masoud, Getlik, Matthäus, Giambruno, Roberto, Grover, Amit, Avellino, Roberto, Skucha, Anna, Vittori, Sarah, Kuznetsova, Ekaterina, Smil, David, Barsyte-Lovejoy, Dalia, Li, Fengling, Poda, Gennadiy, Schapira, Matthieu, Wu, Hong, Dong, Aiping, Senisterra, Guillermo, Stukalov, Alexey, Huber, Kilian V. M., Schönegger, Andreas, Marcellus, Richard, Bilban, Martin, Bock, Christoph, Brown, Peter J., Zuber, Johannes, Bennett, Keiryn L., Al-awar, Rima, Delwel, Ruud, Nerlov, Claus, Arrowsmith, Cheryl H., Superti-Furga, Giulio
Published 2015

The histone chaperone CAF-1 safeguards somatic cell identity

by Cheloufi, Sihem, Elling, Ulrich, Hopfgartner, Barbara, Jung, Youngsook L, Murn, Jernej, Ninova, Maria, Hubmann, Maria, Badeaux, Aimee I, Ang, Cheen Euong, Tenen, Danielle, Wesche, Daniel J, Abazova, Nadezhda, Hogue, Max, Tasdemir, Nilgun, Brumbaugh, Justin, Rathert, Philipp, Jude, Julian, Ferrari, Francesco, Blanco, Andres, Fellner, Michaela, Wenzel, Daniel, Zinner, Marietta, Vidal, Simon E, Bell, Oliver, Stadtfeld, Matthias, Chang, Howard Y., Almouzni, Genevieve, Lowe, Scott W, Rinn, John, Wernig, Marius, Aravin, Alexei, Shi, Yang, Park, Peter, Penninger, Josef M, Zuber, Johannes, Hochedlinger, Konrad
Published 2015