Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

by Filippakopoulos, Panagis, Picaud, Sarah, Fedorov, Oleg, Keller, Marco, Wrobel, Matthias, Morgenstern, Olaf, Bracher, Franz, Knapp, Stefan
Published 2012

Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding

by Kempen, Herman J, Bellus, Daniel, Fedorov, Oleg, Nicklisch, Silke, Filippakopoulos, Panagis, Picaud, Sarah, Knapp, Stefan
Published 2013

Molecular Basis of Histone Tail Recognition by Human TIP5 PHD Finger and Bromodomain of the Chromatin Remodeling Complex NoRC

by Tallant, Cynthia, Valentini, Erica, Fedorov, Oleg, Overvoorde, Lois, Ferguson, Fleur M., Filippakopoulos, Panagis, Svergun, Dmitri I., Knapp, Stefan, Ciulli, Alessio
Published 2015

Flagellar filament bio-templated inorganic oxide materials – towards an efficient lithium battery anode

by Beznosov, Sergei N., Veluri, Pavan S., Pyatibratov, Mikhail G., Chatterjee, Abhijit, MacFarlane, Douglas R., Fedorov, Oleg V., Mitra, Sagar
Published 2015

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

by Fedorov, Oleg, Huber, Kilian, Eisenreich, Andreas, Filippakopoulos, Panagis, King, Oliver, Bullock, Alex N., Szklarczyk, Damian, Jensen, Lars J., Fabbro, Doriano, Trappe, Jörg, Rauch, Ursula, Bracher, Franz, Knapp, Stefan
Published 2011

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes†

by Huber, Kilian, Brault, Laurent, Fedorov, Oleg, Gasser, Christelle, Filippakopoulos, Panagis, Bullock, Alex N., Fabbro, Doriano, Trappe, Jörg, Schwaller, Jürg, Knapp, Stefan, Bracher, Franz
Published 2011

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

by Eswaran, Jeyanthy, Lee, Wen Hwa, Debreczeni, Judit É., Filippakopoulos, Panagis, Turnbull, Andrew, Fedorov, Oleg, Deacon, Sean W., Peterson, Jeffrey R., Knapp, Stefan
Published 2007

Structural and Functional Characterization of the Human Protein Kinase ASK1

by Bunkoczi, Gabor, Salah, Eidarus, Filippakopoulos, Panagis, Fedorov, Oleg, Müller, Susanne, Sobott, Frank, Parker, Sirlester A., Zhang, Haifeng, Min, Wang, Turk, Benjamin E., Knapp, Stefan
Published 2007

3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

by Hewings, David S., Wang, Minghua, Philpott, Martin, Fedorov, Oleg, Uttarkar, Sagar, Filippakopoulos, Panagis, Picaud, Sarah, Vuppusetty, Chaitanya, Marsden, Brian, Knapp, Stefan, Conway, Stuart J., Heightman, Tom D.
Published 2011

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

by Ferguson, Fleur M., Fedorov, Oleg, Chaikuad, Apirat, Philpott, Martin, Muniz, Joao R. C., Felletar, Ildiko, von Delft, Frank, Heightman, Tom, Knapp, Stefan, Abell, Chris, Ciulli, Alessio
Published 2013

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

by Vidler, Lewis R., Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Martin, Sarah, Tomsett, Michael, Woodward, Hannah, Brown, Nathan, Knapp, Stefan, Hoelder, Swen
Published 2013

Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

by Chaikuad, Apirat, Lang, Steffen, Brennan, Paul E., Temperini, Claudia, Fedorov, Oleg, Hollander, Johan, Nachane, Ruta, Abell, Chris, Müller, Susanne, Siegal, Gregg, Knapp, Stefan
Published 2016

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1

by Zhang, Wei, Tyl, Marek, Ward, Richard, Sobott, Frank, Maman, Joseph, Murthy, Andal S., Watson, Aleksandra A., Fedorov, Oleg, Bowman, Andrew, Owen-Hughes, Tom, EL-Mkami, Hassane, Murzina, Natalia V., Norman, David, Laue, Ernest D.
Published 2012

[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of Diverse Bromodomains

by Fedorov, Oleg, Lingard, Hannah, Wells, Chris, Monteiro, Octovia P., Picaud, Sarah, Keates, Tracy, Yapp, Clarence, Philpott, Martin, Martin, Sarah J., Felletar, Ildiko, Marsden, Brian D., Filippakopoulos, Panagis, Müller, Susanne, Knapp, Stefan, Brennan, Paul E.
Published 2013

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

by Ciceri, Pietro, Müller, Susanne, O’Mahony, Alison, Fedorov, Oleg, Filippakopoulos, Panagis, Hunt, Jeremy P., Lasater, Elisabeth A., Pallares, Gabriel, Picaud, Sarah, Wells, Christopher, Martin, Sarah, Wodicka, Lisa M., Shah, Neil P., Treiber, Daniel K., Knapp, Stefan
Published 2014

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

by Bennett, James, Fedorov, Oleg, Tallant, Cynthia, Monteiro, Octovia, Meier, Julia, Gamble, Vicky, Savitsky, Pavel, Nunez-Alonso, Graciela A, Haendler, Bernard, Rogers, Catherine, Brennan, Paul E., Müller, Susanne, Knapp, Stefan
Published 2015

Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

by Drouin, Ludovic, McGrath, Sally, Vidler, Lewis R., Chaikuad, Apirat, Monteiro, Octovia, Tallant, Cynthia, Philpott, Martin, Rogers, Catherine, Fedorov, Oleg, Liu, Manjuan, Akhtar, Wasim, Hayes, Angela, Raynaud, Florence, Müller, Susanne, Knapp, Stefan, Hoelder, Swen
Published 2015

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform

by Wagner, Tobias, Greschik, Holger, Burgahn, Teresa, Schmidtkunz, Karin, Schott, Anne-Kathrin, McMillan, Joel, Baranauskienė, Lina, Xiong, Yan, Fedorov, Oleg, Jin, Jian, Oppermann, Udo, Matulis, Daumantas, Schüle, Roland, Jung, Manfred
Published 2016

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

by Sutherell, Charlotte L., Tallant, Cynthia, Monteiro, Octovia P., Yapp, Clarence, Fuchs, Julian E., Fedorov, Oleg, Siejka, Paulina, Müller, Suzanne, Knapp, Stefan, Brenton, James D., Brennan, Paul E., Ley, Steven V.
Published 2016

The Cryptosporidium parvum Kinome

by Artz, Jennifer D, Wernimont, Amy K, Allali-Hassani, Abdellah, Zhao, Yong, Amani, Mehrnaz, Lin, Yu-Hui, Senisterra, Guillermo, Wasney, Gregory A, Fedorov, Oleg, King, Oliver, Roos, Annette, Lunin, Vlad V, Qiu, Wei, Finerty, Patrick, Hutchinson, Ashley, Chau, Irene, von Delft, Frank, MacKenzie, Farrell, Lew, Jocelyne, Kozieradzki, Ivona, Vedadi, Masoud, Schapira, Matthieu, Zhang, Chao, Shokat, Kevan, Heightman, Tom, Hui, Raymond
Published 2011