Chemical Biology of Lysine Demethylases

by Heightman, Tom D
Published 2011

Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras

by Lebraud, Honorine, Wright, David J., Johnson, Christopher N., Heightman, Tom D.
Published 2016

Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors

by Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Alwi, Sharifah S. Syed, Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E., Heightman, Tom D.
Published 2011

3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

by Hewings, David S., Wang, Minghua, Philpott, Martin, Fedorov, Oleg, Uttarkar, Sagar, Filippakopoulos, Panagis, Picaud, Sarah, Vuppusetty, Chaitanya, Marsden, Brian, Knapp, Stefan, Conway, Stuart J., Heightman, Tom D.
Published 2011

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

by Ferguson, Fleur M., Fedorov, Oleg, Chaikuad, Apirat, Philpott, Martin, Muniz, Joao R. C., Felletar, Ildiko, von Delft, Frank, Heightman, Tom, Knapp, Stefan, Abell, Chris, Ciulli, Alessio
Published 2013

Isoxazole‐Derived Amino Acids are Bromodomain‐Binding Acetyl‐Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3

by Sekirnik (née Measures), Angelina R., Hewings, David S., Theodoulou, Natalie H., Jursins, Lukass, Lewendon, Katie R., Jennings, Laura E., Rooney, Timothy P. C., Heightman, Tom D., Conway, Stuart J.
Published 2016

The Cryptosporidium parvum Kinome

by Artz, Jennifer D, Wernimont, Amy K, Allali-Hassani, Abdellah, Zhao, Yong, Amani, Mehrnaz, Lin, Yu-Hui, Senisterra, Guillermo, Wasney, Gregory A, Fedorov, Oleg, King, Oliver, Roos, Annette, Lunin, Vlad V, Qiu, Wei, Finerty, Patrick, Hutchinson, Ashley, Chau, Irene, von Delft, Frank, MacKenzie, Farrell, Lew, Jocelyne, Kozieradzki, Ivona, Vedadi, Masoud, Schapira, Matthieu, Zhang, Chao, Shokat, Kevan, Heightman, Tom, Hui, Raymond
Published 2011

A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction**

by Rooney, Timothy P C, Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Cortopassi, Wilian A, Hay, Duncan A, Martin, Sarah, Tumber, Anthony, Rogers, Catherine M, Philpott, Martin, Wang, Minghua, Thompson, Amber L, Heightman, Tom D, Pryde, David C, Cook, Andrew, Paton, Robert S, Müller, Susanne, Knapp, Stefan, Brennan, Paul E, Conway, Stuart J
Published 2014