p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

by Iannello, Alexandre, Thompson, Thornton W., Ardolino, Michele, Lowe, Scott W., Raulet, David H.
Published 2013

A common functional consequence of tumor-derived mutations within c-MYC

by Chakraborty, Abhishek A., Scuoppo, Claudio, Dey, Soumyadeep, Thomas, Lance R., Lorey, Shelly L., Lowe, Scott W., Tansey, William. P.
Published 2014

Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice

by Takiguchi, Megumi, Dow, Lukas E., Prier, Julia E., Carmichael, Catherine L., Kile, Benjamin T., Turner, Stephen J., Lowe, Scott W., Huang, David C. S., Dickins, Ross A.
Published 2013

Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice

by Dow, Lukas E., Nasr, Zeina, Saborowski, Michael, Ebbesen, Saya H., Manchado, Eusebio, Tasdemir, Nilgun, Lee, Teresa, Pelletier, Jerry, Lowe, Scott W.
Published 2014

Reversible Suppression of Cyclooxygenase 2 (COX-2) Expression In Vivo by Inducible RNA Interference

by Zaiss, Anne K., Zuber, Johannes, Chu, Chun, Machado, Hidevaldo B., Jiao, Jing, Catapang, Arthur B., Ishikawa, Tomo-o, Gil, Jose S., Lowe, Scott W., Herschman, Harvey R.
Published 2014

TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

by Shirole, Nitin H, Pal, Debjani, Kastenhuber, Edward R, Senturk, Serif, Boroda, Joseph, Pisterzi, Paola, Miller, Madison, Munoz, Gustavo, Anderluh, Marko, Ladanyi, Marc, Lowe, Scott W, Sordella, Raffaella
Published 2016

Direct and indirect targeting of MYC to treat acute myeloid leukemia

by Brondfield, Sam, Umesh, Sushma, Corella, Alexandra, Zuber, Johannes, Rappaport, Amy R., Gaillard, Coline, Lowe, Scott W., Goga, Andrei, Kogan, Scott C.
Published 2015

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia

by Nasr, Zeina, Dow, Lukas E, Paquet, Marilene, Chu, Jennifer, Ravindar, Kontham, Somaiah, Ragam, Deslongchamps, Pierre, Porco Jr, John A, Lowe, Scott W, Pelletier, Jerry
Published 2013

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition

by Bolden, Jessica E., Tasdemir, Nilgun, Dow, Lukas E., van Es, Johan H., Wilkinson, John E., Zhao, Zhen, Clevers, Hans, Lowe, Scott W.
Published 2014

Inducible in vivo genome editing with CRISPR/Cas9

by Dow, Lukas E, Fisher, Jonathan, O'Rourke, Kevin P, Muley, Ashlesha, Kastenhuber, Edward R, Livshits, Geulah, Tschaharganeh, Darjus F, Socci, Nicholas D, Lowe, Scott W
Published 2015

Reciprocal Interaction of Wnt and RXR-α Pathways in Hepatocyte Development and Hepatocellular Carcinoma

by Li, Jinyu, Chanrion, Maia, Sawey, Eric, Wang, Tim, Chow, Edward, Tward, Aaron, Su, Yi, Xue, Wen, Lucito, Robert, Zender, Lars, Lowe, Scott W., Bishop, J. Michael, Powers, Scott
Published 2015

Gene Mutations and Genomic Rearrangements in the Mouse as a Result of Transposon Mobilization from Chromosomal Concatemers

by Geurts, Aron M, Collier, Lara S, Geurts, Jennifer L, Oseth, Leann L, Bell, Matthew L, Mu, David, Lucito, Robert, Godbout, Susan A, Green, Laura E, Lowe, Scott W, Hirsch, Betsy A, Leinwand, Leslie A, Largaespada, David A
Published 2006

Cooperative loss of RAS feedback regulation drives myeloid leukemognesis

by Zhao, Zhen, Chen, Chi-Chao, Rillahan, Cory D., Shen, Ronglai, Kitzing, Thomas, McNerney, Megan E., Diaz-Flores, Ernesto, Zuber, Johannes, Shannon, Kevin, Le Beau, Michelle M., Spector, Mona S., Kogan, Scott C., Lowe, Scott W.
Published 2015

PTEN action in leukemia dictated by the tissue microenvironment

by Miething, Cornelius, Scuoppo, Claudio, Bosbach, Benedikt, Appelmann, Iris, Nakitandwe, Joy, Ma, Jing, Wu, Gang, Lintault, Laura, Auer, Martina, Premsrirut, Prem K., Teruya-Feldstein, Julie, Hicks, James, Benveniste, Helene, Speicher, Michael R., Downing, James R., Lowe, Scott W.
Published 2014

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

by Maddalo, Danilo, Manchado, Eusebio, Concepcion, Carla P., Bonetti, Ciro, Vidigal, Joana A., Han, Yoon-Chi, Ogrodowski, Paul, Crippa, Alessandra, Rekhtman, Natasha, de Stanchina, Elisa, Lowe, Scott W., Ventura, Andrea
Published 2014

A combinatorial strategy for treating KRAS mutant lung cancer

by Manchado, Eusebio, Weissmueller, Susann, Morris, John P., Chen, Chi-Chao, Wullenkord, Ramona, Lujambio, Amaia, de Stanchina, Elisa, Poirier, John T., Gainor, Justin F., Corcoran, Ryan B., Engelman, Jeffrey A., Rudin, Charles M., Rosen, Neal, Lowe, Scott W.
Published 2016

Two Distinct Categories of Focal Deletions in Cancer Genomes

by Rajaram, Megha, Zhang, Jianping, Wang, Tim, Li, Jinyu, Kuscu, Cem, Qi, Huan, Kato, Mamoru, Grubor, Vladimir, Weil, Robert J., Helland, Aslaug, Borrenson-Dale, Anne-Lise, Cho, Kathleen R., Levine, Douglas A., Houghton, Alan N., Wolchok, Jedd D., Myeroff, Lois, Markowitz, Sanford D., Lowe, Scott W., Zhang, Michael, Krasnitz, Alex, Lucito, Robert, Mu, David, Powers, R. Scott
Published 2013

Mutation discovery in mice by whole exome sequencing

by Fairfield, Heather, Gilbert, Griffith J, Barter, Mary, Corrigan, Rebecca R, Curtain, Michelle, Ding, Yueming, D'Ascenzo, Mark, Gerhardt, Daniel J, He, Chao, Huang, Wenhui, Richmond, Todd, Rowe, Lucy, Probst, Frank J, Bergstrom, David E, Murray, Stephen A, Bult, Carol, Richardson, Joel, Kile, Benjamin T, Gut, Ivo, Hager, Jorg, Sigurdsson, Snaevar, Mauceli, Evan, Di Palma, Federica, Lindblad-Toh, Kerstin, Cunningham, Michael L, Cox, Timothy C, Justice, Monica J, Spector, Mona S, Lowe, Scott W, Albert, Thomas, Donahue, Leah Rae, Jeddeloh, Jeffrey, Shendure, Jay, Reinholdt, Laura G
Published 2011

The histone chaperone CAF-1 safeguards somatic cell identity

by Cheloufi, Sihem, Elling, Ulrich, Hopfgartner, Barbara, Jung, Youngsook L, Murn, Jernej, Ninova, Maria, Hubmann, Maria, Badeaux, Aimee I, Ang, Cheen Euong, Tenen, Danielle, Wesche, Daniel J, Abazova, Nadezhda, Hogue, Max, Tasdemir, Nilgun, Brumbaugh, Justin, Rathert, Philipp, Jude, Julian, Ferrari, Francesco, Blanco, Andres, Fellner, Michaela, Wenzel, Daniel, Zinner, Marietta, Vidal, Simon E, Bell, Oliver, Stadtfeld, Matthias, Chang, Howard Y., Almouzni, Genevieve, Lowe, Scott W, Rinn, John, Wernig, Marius, Aravin, Alexei, Shi, Yang, Park, Peter, Penninger, Josef M, Zuber, Johannes, Hochedlinger, Konrad
Published 2015

Convergent loss of PTEN leads to clinical resistance to a PI3Kα inhibitor

by Juric, Dejan, Castel, Pau, Griffith, Malachi, Griffith, Obi L., Won, Helen H., Ellis, Haley, Ebbesen, Saya H., Ainscough, Benjamin J., Ramu, Avinash, Iyer, Gopa, Shah, Ronak H., Huynh, Tiffany, Mino-Kenudson, Mari, Sgroi, Dennis, Isakoff, Steven, Thabet, Ashraf, Elamine, Leila, Solit, David B., Lowe, Scott W., Quadt, Cornelia, Peters, Malte, Derti, Adnan, Schegel, Robert, Huang, Alan, Mardis, Elaine R., Berger, Michael F., Baselga, José, Scaltriti., Maurizio
Published 2014