The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation
Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokin...
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| Format: | Online |
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The Rockefeller University Press
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915194/ |
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pubmed-49151942016-12-20 The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation Sharma, Deepika Kanneganti, Thirumala-Devi Reviews Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokines, IL-1β and IL-18, and induction of an inflammatory form of cell death called pyroptosis. Recent studies have highlighted the intersection of this inflammatory response with fundamental cellular processes. Novel modulators and functions of inflammasome activation conventionally associated with the maintenance of homeostatic biological functions have been uncovered. In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome. The Rockefeller University Press 2016-06-20 /pmc/articles/PMC4915194/ /pubmed/27325789 http://dx.doi.org/10.1083/jcb.201602089 Text en © 2016 Sharma and Kanneganti This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sharma, Deepika Kanneganti, Thirumala-Devi |
| spellingShingle |
Sharma, Deepika Kanneganti, Thirumala-Devi The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation |
| author_facet |
Sharma, Deepika Kanneganti, Thirumala-Devi |
| author_sort |
Sharma, Deepika |
| title |
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation |
| title_short |
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation |
| title_full |
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation |
| title_fullStr |
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation |
| title_full_unstemmed |
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation |
| title_sort |
cell biology of inflammasomes: mechanisms of inflammasome activation and regulation |
| description |
Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokines, IL-1β and IL-18, and induction of an inflammatory form of cell death called pyroptosis. Recent studies have highlighted the intersection of this inflammatory response with fundamental cellular processes. Novel modulators and functions of inflammasome activation conventionally associated with the maintenance of homeostatic biological functions have been uncovered. In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome. |
| publisher |
The Rockefeller University Press |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915194/ |
| _version_ |
1613597526657597440 |