Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation

While the molecular mechanisms promoting activation of the Nod-like Receptor (NLR) family member NLRP3 inflammasome are beginning to be defined, little is known about the mechanisms that regulate the NLRP3 inflammasome. Acute (up to 4 hours) LPS stimulation, followed by ATP is frequently used to act...

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Bibliographic Details
Main Authors: Gurung, Prajwal, Li, Bofeng, Subbarao Malireddi, R. K., Lamkanfi, Mohamed, Geiger, Terrence L., Kanneganti, Thirumala-Devi
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585974/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585974/

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