Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression

Inflammasomes are cytoplasmic, multiprotein complexes that trigger caspase-1 activation and IL-1β maturation in response to diverse stimuli. Although inflammasomes play important roles in host defense against microbial infection, overactive inflammasomes are deleterious and lead to various autoinfla...

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Main Authors: Yu, Shui-Xing, Du, Chong-Tao, Chen, Wei, Lei, Qian-Qian, Li, Ning, Qi, Shuai, Zhang, Xiao-Jing, Hu, Gui-Qiu, Deng, Xu-Ming, Han, Wen-Yu, Yang, Yong-Jun
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675967/

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