Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG
Two mammalian DNA glycosylases, methyl-CpG binding domain protein 4 (MBD4) and thymine DNA glycosylase (TDG), are involved in active DNA demethylation via the base excision repair pathway. Both MBD4 and TDG excise the mismatch base from G:X, where X is uracil, thymine, and 5-hydroxymethyluracil (5hm...
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| Format: | Online |
| Language: | English |
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The Biophysical Society of Japan (BSJ)
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629659/ |