Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
DNA 5-methylcytosine is a dynamic epigenetic mark which plays important roles in development and disease. In the Tet-Tdg demethylation pathway, methylated cytosine is iteratively oxidized by Tet dioxygenases and unmodified cytosine is restored via thymine DNA glycosylase (Tdg). Here we show that hum...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894546/ |