No Evidence for AID/MBD4-Coupled DNA Demethylation in Zebrafish Embryos

The mechanisms responsible for active DNA demethylation remain elusive in Metazoa. A previous study that utilized zebrafish embryos provided a potent mechanism for active demethylation in which three proteins, AID, MBD4, and GADD45 are involved. We recently found age-dependent DNA hypomethylation in...

Full description

Bibliographic Details
Main Authors: Shimoda, Nobuyoshi, Hirose, Kentaro, Kaneto, Reiya, Izawa, Toshiaki, Yokoi, Hayato, Hashimoto, Naohiro, Kikuchi, Yutaka
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275248/