Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA

Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA

Thymine DNA Glycosylase (TDG) performs essential functions in maintaining genetic integrity and epigenetic regulation. Initiating base excision repair, TDG removes thymine from mutagenic G·T mispairs caused by 5-methylcytosine (mC) deamination and other lesions including uracil (U) and 5-hydroxymeth...

Full description

Bibliographic Details
Main Authors:	Malik, Shuja S., Coey, Christopher T., Varney, Kristen M., Pozharski, Edwin, Drohat, Alexander C.
Format:	Online
Language:	English
Published:	Oxford University Press 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627079/

Similar Items

Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues
by: Coey, Christopher T., et al.
Published: (2016)

Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNA
by: Morgan, Michael T., et al.
Published: (2011)

Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging
by: Buechner, Claudia N., et al.
Published: (2015)

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
by: Zhang, Liang, et al.
Published: (2012)

How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA
by: Drohat, Alexander C., et al.
Published: (2012)

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair
by: Li, Ya-Qiang, et al.
Published: (2007)

Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation
by: Hashimoto, Hideharu, et al.
Published: (2012)

Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation
by: Hashimoto, Hideharu, et al.
Published: (2012)

DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations
by: Fortes, F.P., et al.
Published: (2015)

Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA
by: Moréra, Solange, et al.
Published: (2012)

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase
by: Raiber, Eun-Ang, et al.
Published: (2012)

The Hepatitis B Virus X Protein Inhibits Thymine DNA Glycosylase Initiated Base Excision Repair
by: van de Klundert, Maarten A. A., et al.
Published: (2012)

Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase
by: Liu, Yun, et al.
Published: (2016)

A Germline Polymorphism of Thymine DNA Glycosylase Induces Genomic Instability and Cellular Transformation
by: Sjolund, Ashley, et al.
Published: (2014)

MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA
by: Markkanen, Enni, et al.
Published: (2013)

DNA glycosylases: in DNA repair and beyond
by: Jacobs, Angelika L., et al.
Published: (2011)

Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase
by: Setser, Jeremy W., et al.
Published: (2011)

7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases
by: Talhaoui, Ibtissam, et al.
Published: (2013)

Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands
by: Talhaoui, Ibtissam, et al.
Published: (2014)

The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase
by: Guan, Xin, et al.
Published: (2007)

Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA
by: Shimizu, Tatsuhiko, et al.
Published: (2006)

Double threading through DNA: NMR structural study of a bis-naphthalene macrocycle bound to a thymine–thymine mismatch
by: Jourdan, Muriel, et al.
Published: (2012)

A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks
by: Alzeer, Jawad, et al.
Published: (2006)

Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
by: Kachhap, Sushant, et al.
Published: (2004)

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation
by: Ba, Xueqing, et al.
Published: (2014)

Thermodynamics of the DNA Damage Repair Steps of Human 8-Oxoguanine DNA Glycosylase
by: Kuznetsov, Nikita A., et al.
Published: (2014)

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
by: Schomacher, Lars, et al.
Published: (2016)

Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA Glycosylase
by: Schormann, Norbert, et al.
Published: (2015)

A unique uracil-DNA binding protein of the uracil DNA glycosylase superfamily
by: Sang, Pau Biak, et al.
Published: (2015)

6-Pyrazolylpurine as an Artificial Nucleobase for Metal-Mediated Base Pairing in DNA Duplexes
by: Léon, J. Christian, et al.
Published: (2016)

DNA Bases Thymine and Adenine in Bio-Organic Light Emitting Diodes
by: Gomez, Eliot F., et al.
Published: (2014)

The structure of metallo-DNA with consecutive thymine–HgII–thymine base pairs explains positive entropy for the metallo base pair formation
by: Yamaguchi, Hiroshi, et al.
Published: (2014)

N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts
by: Rinne, M. L., et al.
Published: (2005)

Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair
by: Bulgar, A D, et al.
Published: (2012)

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
by: Zhou, Jia, et al.
Published: (2015)

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
by: Zhou, Jia, et al.
Published: (2015)

A structural determinant in the uracil DNA glycosylase superfamily for the removal of uracil from adenine/uracil base pairs
by: Lee, Dong-Hoon, et al.
Published: (2015)

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase
by: Do, Hongdo, et al.
Published: (2012)

Microhydration of Deprotonated Nucleobases
by: Wincel, Henryk
Published: (2016)

T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif
by: Lucey, Marie J., et al.
Published: (2005)