Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase
Non-reproducible sequence artefacts are frequently detected in DNA from formalin-fixed and paraffin-embedded (FFPE) tissues. However, no rational strategy has been developed for reduction of sequence artefacts from FFPE DNA as the underlying causes of the artefacts are poorly understood. As cytosine...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388184/ |