Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma

Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma

Aberrant hedgehog signaling contributes to the development of various malignancies, including glioblastoma (GBM). However, the potential mechanism of hedgehog signaling in GBM migration and invasion has remained to be elucidated. The present study showed that enhanced hedgehog signaling by recombina...

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Bibliographic Details
Main Authors: CHANG, LIANG, ZHAO, DAN, LIU, HUI-BIN, WANG, QIU-SHI, ZHANG, PING, LI, CHEN-LONG, DU, WEN-ZHONG, WANG, HONG-JUN, LIU, XING, ZHANG, ZHI-REN, JIANG, CHUAN-LU
Format: Online
Language:English
Published: D.A. Spandidos 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626128/

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