Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells

Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells

Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat). In a pancreatic ductal adenocarcinoma (PDAC) ce...

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Bibliographic Details
Main Authors: Konitsiotis, Antonios D., Chang, Shu-Chun, Jovanović, Biljana, Ciepla, Paulina, Masumoto, Naoko, Palmer, Christopher P., Tate, Edward W., Couchman, John R., Magee, Anthony I.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946499/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946499/

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