Signaling Domain of Sonic Hedgehog as Cannibalistic Calcium-Regulated Zinc-Peptidase

Sonic Hedgehog (Shh) is a representative of the evolutionary closely related class of Hedgehog proteins that have essential signaling functions in animal development. The N-terminal domain (ShhN) is also assigned to the group of LAS proteins (LAS = Lysostaphin type enzymes, D-Ala-D-Ala metalloprotea...

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Bibliographic Details
Main Authors: Rebollido-Rios, Rocio, Bandari, Shyam, Wilms, Christoph, Jakuschev, Stanislav, Vortkamp, Andrea, Grobe, Kay, Hoffmann, Daniel
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102407/