Detection of Canonical Hedgehog Signaling in Breast Cancer by 131-Iodine-Labeled Derivatives of the Sonic Hedgehog Protein

Detection of Canonical Hedgehog Signaling in Breast Cancer by 131-Iodine-Labeled Derivatives of the Sonic Hedgehog Protein

Activation of hedgehog (HH) pathway signaling is observed in many tumors. Due to a feedback loop, the HH receptor Patched (PTCH-1) is overexpressed in tumors with activated HH signaling. Therefore, we sought to radiolabel the PTCH-1 ligand sonic (SHH) for detection of cancer cells with canonical HH...

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Bibliographic Details
Main Authors: Sims-Mourtada, Jennifer, Yang, David, Tworowska, Izabela, Larson, Richard, Smith, Daniel, Tsao, Ning, Opdenaker, Lynn, Mourtada, Firas, Woodward, Wendy
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395403/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395403/

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