Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1

Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1

Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization. PLCs are classified into structurally distinct β, γ, δ, ε, ζ, and η isoforms. There are two PLCγ isoforms (PLCγ1, PLCγ2), which are critical fo...

Full description

Bibliographic Details
Main Authors:	Zheng, Yongwei, Adams, Tamara, Zhi, Huiying, Yu, Mei, Wen, Renren, Newman, Peter J., Wang, Demin, Newman, Debra K.
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368822/

Similar Items

Association study with Wegener granulomatosis of the human phospholipase Cγ2 gene
by: Jagiello, Peter, et al.
Published: (2005)

Calcium Release at Fertilization in Starfish Eggs Is Mediated by Phospholipase Cγ
by: Carroll, David J., et al.
Published: (1997)

Phospholipase Cγ2 is required for basal but not oestrogen deficiency–induced bone resorption
by: Kertész, Zsuzsanna, et al.
Published: (2012)

Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D
by: Razmara, Masoud, et al.
Published: (2013)

Disruption of Phosphoinositide-Specific Phospholipases Cγ1 Contributes to Extracellular Matrix Synthesis of Human Osteoarthritis Chondrocytes
by: Zeng, Guoqing, et al.
Published: (2014)

Suppression of Phospholipase Dγs Confers Increased Aluminum Resistance in Arabidopsis thaliana
by: Zhao, Jian, et al.
Published: (2011)

Angiotensin II-induced delayed stimulation of phospholipase C γ1 requires activation of both phosphatidiylinositol 3-kinase γ and tyrosine kinase in vascular myocytes
by: Rakotoarisoa, Lala, et al.
Published: (2006)

Insulin Receptor-Mediated Signaling via Phospholipase C-γ Regulates Growth and Differentiation in Drosophila
by: Murillo-Maldonado, Juan M., et al.
Published: (2011)

Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection
by: Sommers, Connie L., et al.
Published: (2005)

Coupling Between B Cell Receptor and Phospholipase C-γ2 Is Essential for Mature B Cell Development
by: Hikida, Masaki, et al.
Published: (2003)

Cbl-b Positively Regulates Btk-mediated Activation of Phospholipase C-γ2 in B Cells
by: Yasuda, Tomoharu, et al.
Published: (2002)

γ-Synuclein Interacts with Phospholipase Cβ2 to Modulate G Protein Activation
by: Golebiewska, Urszula, et al.
Published: (2012)

Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca2+ mobilization
by: Smith, Norah L., et al.
Published: (2013)

Phospholipase C γ1 regulates early secretory trafficking and cell migration via interaction with p115
by: Millarte, Valentina, et al.
Published: (2015)

Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice
by: Ichise, Hirotake, et al.
Published: (2016)

Effect of acute acid-base disturbances on the phosphorylation of phospholipase C-γ1 and Erk1/2 in the renal proximal tubule
by: Skelton, Lara A, et al.
Published: (2015)

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway
by: Kumari, Sudha, et al.
Published: (2015)

Alopecia in a Viable Phospholipase C Delta 1 and Phospholipase C Delta 3 Double Mutant
by: Runkel, Fabian, et al.
Published: (2012)

Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy
by: Nakamura, Y, et al.
Published: (2014)

Role of phospholipase C in cell invasion and metastasis
by: Lattanzio, R., et al.
Published: (2013)

Phospholipase C?1 is required for metastasis development and progression
by: Sala, G., et al.
Published: (2008)

Phospholipase C in Beijing strains of Mycobacterium tuberculosis
by: Goudarzi, H, et al.
Published: (2010)

Phospholipase Cδ regulates germination of Dictyostelium spores
by: Van Dijken, Peter, et al.
Published: (2001)

Phospholipase C-β1 Hypofunction in the Pathogenesis of Schizophrenia
by: Kim, Seong-Wook, et al.
Published: (2015)

Involvement of Phospholipase Cγ1 in Mouse Egg Activation Induced by a Truncated Form of the C-kit Tyrosine Kinase Present in Spermatozoa
by: Sette, Claudio, et al.
Published: (1998)

Inhibition of human platelet phospholipase A2 by mono(2-ethylhexyl)phthalate.
by: Labow, R S, et al.
Published: (1988)

Si Shen Wan Regulates Phospholipase Cγ-1 and PI3K/Akt Signal in Colonic Mucosa from Rats with Colitis
by: Liu, Duan-yong, et al.
Published: (2015)

Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone
by: Kavok, Nataliya S, et al.
Published: (2001)

Group VIB Calcium-Independent Phospholipase A2 (iPLA2γ) Regulates Platelet Activation, Hemostasis and Thrombosis in Mice
by: Yoda, Emiko, et al.
Published: (2014)

Convergence of αvβ3Integrin–And Macrophage Colony Stimulating Factor–Mediated Signals on Phospholipase Cγ in Prefusion Osteoclasts
by: Nakamura, Ichiro, et al.
Published: (2001)

Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-γ2 to Ras in B Cell Receptor Signaling
by: Oh-hora, Masatsugu, et al.
Published: (2003)

Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways
by: Reynolds, Lucinda F., et al.
Published: (2002)

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization
by: Pérez-Quintero, Luis-Alberto, et al.
Published: (2014)

Phospholipase Cγ2 is critical for Ca2+ flux and cytokine production in anti-fungal innate immunity of human corneal epithelial cells
by: Xudong Peng, et al.
Published: (2018-07-01)

Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway
by: Ertao, Zhai, et al.
Published: (2016)

Cbl Suppresses B Cell Receptor–Mediated Phospholipase C (Plc)-γ2 Activation by Regulating B Cell Linker Protein–Plc-γ2 Binding
by: Yasuda, Tomoharu, et al.
Published: (2000)

Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation
by: Bechler, Marie E., et al.
Published: (2014)

Phospholipases in Signal Transduction
by: Corda, D., et al.
Published: (2008)

Phospholipases A in Trypanosomatids
by: Belaunzarán, María Laura, et al.
Published: (2011)

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation
by: Mouneimne, Ghassan, et al.
Published: (2004)