Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy

Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy

Phospholipase C (PLC) is a key enzyme in phosphoinositide turnover. Among 13 PLC isozymes, PLCδ1 and PLCδ3 share high sequence homology and similar tissue distribution, and are expected to have functional redundancy in many tissues. We previously reported that the simultaneous loss of PLCδ1 and PLCδ...

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Bibliographic Details
Main Authors: Nakamura, Y, Kanemaru, K, Kojima, R, Hashimoto, Y, Marunouchi, T, Oka, N, Ogura, T, Tanonaka, K, Fukami, K
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047916/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047916/

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