Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection

Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of type I IFNs has been studied in the pathogenesis of both acute and chronic microbial infections. Deregulated type I IFN production results in a damaging cascade of cell death, inflammation, and immunological...

Full description

Bibliographic Details
Main Authors:	Malireddi, R. K. Subbarao, Kanneganti, Thirumala-Devi
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824101/

id	pubmed-3824101
recordtype	oai_dc
spelling	pubmed-38241012013-11-22 Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection Malireddi, R. K. Subbarao Kanneganti, Thirumala-Devi Microbiology Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of type I IFNs has been studied in the pathogenesis of both acute and chronic microbial infections. Deregulated type I IFN production results in a damaging cascade of cell death, inflammation, and immunological host responses that can lead to tissue injury and disease progression. Here, we summarize the role of type I IFNs in the regulation of cell death and disease during different microbial infections, ranging from viruses and bacteria to fungal pathogens. Understanding the specific mechanisms driving type I IFN-mediated cell death and disease could aid in the development of targeted therapies. Frontiers Media S.A. 2013-11-12 /pmc/articles/PMC3824101/ /pubmed/24273750 http://dx.doi.org/10.3389/fcimb.2013.00077 Text en Copyright © 2013 Malireddi and Kanneganti. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Malireddi, R. K. Subbarao Kanneganti, Thirumala-Devi
spellingShingle	Malireddi, R. K. Subbarao Kanneganti, Thirumala-Devi Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection
author_facet	Malireddi, R. K. Subbarao Kanneganti, Thirumala-Devi
author_sort	Malireddi, R. K. Subbarao
title	Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection
title_short	Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection
title_full	Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection
title_fullStr	Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection
title_full_unstemmed	Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection
title_sort	role of type i interferons in inflammasome activation, cell death, and disease during microbial infection
description	Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of type I IFNs has been studied in the pathogenesis of both acute and chronic microbial infections. Deregulated type I IFN production results in a damaging cascade of cell death, inflammation, and immunological host responses that can lead to tissue injury and disease progression. Here, we summarize the role of type I IFNs in the regulation of cell death and disease during different microbial infections, ranging from viruses and bacteria to fungal pathogens. Understanding the specific mechanisms driving type I IFN-mediated cell death and disease could aid in the development of targeted therapies.
publisher	Frontiers Media S.A.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824101/
_version_	1612025613682475008

Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection

Similar Items