Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

Multi-protein complexes called inflammasomes have recently been identified and shown to contribute to cell death in tissue injury. Intravenous immunoglobulin (IVIg) is an FDA-approved therapeutic modality used for various inflammatory diseases. The objective of this study is to investigate dynamic r...

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Bibliographic Details
Main Authors: Yang-Wei Fann, D, Lee, S-Y, Manzanero, S, Tang, S-C, Gelderblom, M, Chunduri, P, Bernreuther, C, Glatzel, M, Cheng, Y-L, Thundyil, J, Widiapradja, A, Lok, K-Z, Foo, S L, Wang, Y-C, Li, Y-I, Drummond, G R, Basta, M, Magnus, T, Jo, D-G, Mattson, M P, Sobey, C G, Arumugam, T V
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789184/

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