Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years. With a five-year survival rate of 15%, identification of new therapeutic targets for EAC is greatly important. We analyze the mutation spectra from whole exome sequencing of 149 EAC tumors/normal pairs, 15 of whi...
Main Authors: | Dulak, Austin M., Stojanov, Petar, Peng, Shouyong, Lawrence, Michael S., Fox, Cameron, Stewart, Chip, Bandla, Santhoshi, Imamura, Yu, Schumacher, Steven E., Shefler, Erica, McKenna, Aaron, Cibulskis, Kristian, Sivachenko, Andrey, Carter, Scott L., Saksena, Gordon, Voet, Douglas, Ramos, Alex H., Auclair, Daniel, Thompson, Kristin, Sougnez, Carrie, Onofrio, Robert C., Guiducci, Candace, Beroukhim, Rameen, Zhou, David, Lin, Lin, Lin, Jules, Reddy, Rishindra, Chang, Andrew, Luketich, James D., Pennathur, Arjun, Ogino, Shuji, Golub, Todd R., Gabriel, Stacey B., Lander, Eric S., Beer, David G., Godfrey, Tony E., Getz, Gad, Bass, Adam J. |
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Format: | Online |
Language: | English |
Published: |
2013
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678719/ |
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